Penn Medicine Cleanroom Design | AES Clean Technology

BioPharma

Helping Biopharmaceutical Teams Speed Up Builds, Reduce Risk, and Meet Strict Regulatory Expectations

Life Sciences

AES Delivers Cleanroom Environments That Match the Pace and Complexity of Life Sciences

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Advanced Technology

High-Performance Cleanroom Environments for Innovators in Semiconductors, Microelectronics and EV Batteries

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Architectural Design

Architectural Expertise for Seamless Cleanroom Delivery

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Engineering

In-House Engineering Solutions That Power Safe, Scalable, and Compliant Cleanroom Operations

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Pre-Construction

Turning Complex Requirements Into Actionable Plans Through Expert Pre-Construction Planning

Construction

Modular Cleanroom Construction Built for Regulated Environments and High-Performance

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Service & Maintenance

From routine maintenance to emergency repairs, our support solves potential disruptions before they become critical issues.

Conceptual Facility Planning

AES delivers integrated design solutions that build efficient, compliant foundations for your cleanroom success.

Modular Architectural System

AES’s modular panels offer fast, scalable, compliant cleanroom solutions.

Turnkey Cleanrooms

AES delivers turnkey cleanrooms with integrated HVAC, streamlining projects from concept to completion.

Walls & Ceilings

Precision-engineered cleanroom walls and ceilings for durability, compliance, and fast installation.

Windows & Doors

AES designs GMP-compliant cleanroom windows and doors for safety, access, and clarity.

Lighting

Cleanroom lighting engineered for superior visibility, safety, and GMP compliance.

Off-Site Manufacturing

Modular cleanroom components built off-site for faster installs, minimal disruption, and quality assurance.

Integrated Components

Specialized components to customize and enhance your cleanroom solution.

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Project

Penn Medicine

PENN Medicine created its Clinical Cell and Vaccine Production Facility within the South Tower of the Perelman Center for Advanced Medicine located in the heart of PENN’s campus in Philadelphia. The CVPF includes administrative, research, development, and GMP manufacturing operations within this sixteen-story building, and is the birthplace of Kymriah, the FDA-approved treatment for pediatric ALL and large B-cell lymphoma.  The facility includes a custom-designed and constructed Clinical Manufacturing cleanroom core for producing PENN’s cell and gene therapy candidates.  The GMP manufacturing suite was developed from its inception by AES, leveraging our expertise in immunotherapy manufacturing facilities that are breaking down barriers for patients with life-threatening illnesses.  The AES project features included:

  • AES Pharma Modular Architectural Envelope
  • Dedicated Mechanical Systems and HEPA Filtration to create isolated suites for multi-product and multi-patient manufacturing
  • Flush cleanroom Window Details Coordinated with South Tower’s Curtain Wall System to Preserve Views of the Philadelphia Skyline
  • Integration of Process Utilities within the Cleanroom Suite
  • Custom Pass-Thru Chambers
  • Epoxy Flooring with Radius Coving
  • Cleanroom Lighting and Electrical Distribution
  • Engineering, Site Project Management
  • Cleanroom commissioning

 

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